The Transgender Dictionary

DIRECTORY W.I.P.!!! # A B C D E F G H I J K L M N O P Q R S T U V W X Y Z RESOURCES BY COUNTRY MISCELLANEOUS

Aromatase Deficiency Syndrome

(also: hyperestrogenism, AEXS, AES)

Table of Contents

General Information

Someone with aromatase excess has an increased production of aromatase, the enzyme responsible for aromatization. This generally due to mutations of the CYP19A1 gene. Aromatase excess is a genetic condition. Fertility is typically normal.

The body of somoene with XY chromosomes and aromatase excess will therefore have more active estrogen than the body of a person with XY chromosomes and typical levels of aromatase. As estrogen is responsible for the closing of the bones' growth plates, someone with aromatase excess syndrome will often stop growing at a shorter height. They may experience gynecomastia in adolescence, along with features associated with a typical testosterone-based puberty. Hyperestrogenism was formerly referred to as "familia gynecomastia" due to the development of breasts in those with XY chromosomes being one of the most recognizable effects. They will typically have two testes, and have both external and internal genitalia that is typical for those who were AMAB. However, it is possible for a person with XY chromosomes and aromatase excess to have mild hypospadias and/or a micropenis.

The body of someone with both an aromatase excess and XX chromosomes does not typically have sex characteristics that vary dramatically from that of someone without aromatase excess going through a typical estrogen-based puberty. That being said, someone with XX chromosomes and aromatase excess may experience breast enlargment, a short stature, and potential menstrual irregularities. It may result in agenital-like variations such as vaginal septums, vaginal hyperplasia (abnormal growth of the vaginal lining), or variations of the hymen.

Flag

The resources below have been provided for education, information sourcing, and entertainment purposes. The views expressed in these videos, websites, etc, do not inherently reflect those of The Transgender Dictionary. These resources are not sponsored, nor endorsed.

Additional Resources