The body of someone with estrogen insensitivity syndrome does not respond to estrogen.
The body of someone with EIS and XX chromosomes is usually born with a vulva and vagina. They may have a small uterus, and enlarged ovaries that later develop multiple cysts. They may produce very high levels of estrogen that their bodies do not recognize. They may not experience the changes that are associated with a typical estrogen-based puberty; such as breast development or menstruation. They may develop pubic hair and acne due to the influence of androgens.
The body of someone with EIS and XY chromosomes may or may not experience variations in their other hormone production, testicular development, and development of secondary sex characteristics.
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