The Transgender Dictionary

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XXYY Syndrome

(also: Tetrasomy XXYY)

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General Information

Someone with this intersex variation is born with an extra copy of both they X and Y chromosomes, resulting in a 48XXYY chromosome pattern instead of the typical 46XY. Those with this chromosomal pattern may often have undecended testes, and produce lower-than-typical levels of testosterone, which can cause them to start puberty at a later age than typical, and to develop less pronounced secondary sex characteristics (such as muscle tone and facial hair). They may also experience breast growth. Those with XXYY Syndrome may often have other physical features that are similar to those developed by people with Klinefelter Syndrome (47XXY).

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